Mediators involved in the immunomodulatory effects of apoptotic cells.

Date publication

juillet 2007

Journal

Transplantation

Auteurs

Membres identifiés du Cancéropôle Est :
Dr PERRUCHE Sylvain

Tous les auteurs :
Saas P, Bonnefoy F, Kury-Paulin S, Kleinclauss F, Perruche S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/17632410

Résumé

Immunomodulatory properties are attributed to apoptotic cells. These properties have been used to modulate allogeneic immune responses in experimental transplantation settings. In independent studies, apoptotic cell infusion has been shown to favor hematopoietic cell engraftment, to increase heart graft survival, and to delay the lethal onset of graft-versus-host disease (GVHD). The goal of this review was to discuss how apoptotic cell infusion interferes with graft rejection or host rejection (i.e., GVHD) and to focus on the potential mediators or "perpetuators" involved in apoptotic cell-induced immunomodulation. Particular emphasis on apoptotic cell phagocytosis, transforming growth factor (TGF)-beta secretion, and regulatory T cell induction was performed. Stimulating "naturally" immunosuppressive molecules (i.e., TGF-beta) or immunomodulatory cells ("alternatively-activated" macrophages, certain dendritic cell subsets, or regulatory T cells) in a physiological manner by using apoptotic cell infusion can be a promising way to induce tolerance.

Mots clés

Animals, Apoptosis, immunology, Cell Transplantation, Immune Tolerance, immunology, Transcription, Genetic, genetics, Transforming Growth Factor beta, genetics

Référence

Transplantation. 2007 Jul;84(1 Suppl):S31-4