Enrolling study personnel in Ebola vaccine trials: from guidelines to practice in a non-epidemic context.

Date publication

juillet 2019

Journal

Trials

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DABAKUYO-YONLI Sandrine

Tous les auteurs :
Lhomme E, Modet C, Augier A, Faye S, Dabakuyo-Yonli TS, Levy-Marchal C, D'Ortenzio E, Yazdanpanah Y, Chêne G, Beavogui AH, Richert L,

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31296253

Résumé

Enrolling participants in clinical trials can be challenging, especially with respect to prophylactic vaccine trials. The vaccination of study personnel in Ebola vaccine trials during the 2014-2016 epidemic played a crucial role in inspiring trust and facilitating volunteer enrollment. We evaluated the ethical and methodological considerations as they applied to an ongoing phase 2 randomized prophylactic Ebola vaccine trial that enrolled healthy volunteers in Guinea, Liberia, Sierra Leone, and Mali in a non-epidemic context.

Mots clés

Clinical trials, Ebola vaccine, Employees, Ethics, Health workers, Low- and middle-income countries, Research participants, Site staff, Trial participants

Référence

Trials. 2019 Jul 11;20(1):422