Fiche publication
Date publication
juillet 2019
Journal
Fitoterapia
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MORJANI Hamid
Tous les auteurs :
Bitchi MB, Magid AA, Yao-Kouassi PA, Kabran FA, Harakat D, Martinez A, Morjani H, Tonzibo FZ, Voutquenne-Nazabadioko L
Lien Pubmed
Résumé
Five undescribed triterpene-type saponins, parkibicolorosides A-E, a cassane-type diterpene, and a known trimethoxy benzene glucoside were isolated from the roots of Parkia bicolor A. Chev. Their structures were elucidated by different spectroscopic methods including 1D- and 2D-NMR experiments as well as HR-ESI-MS analysis. Their cytotoxic activity against the chronic myeloid leukemia (K562) cell line was evaluated. The monosaccharides saponins exhibited a moderate antiproliferative activity with IC ranging from 48.49 ± 0.16 to 81.66 ± 0.17 μM.
Mots clés
Cytotoxic activity, Diterpene, Fabaceae, Parkia bicolor, Triterpenoid saponins
Référence
Fitoterapia. 2019 Jul 9;:104264
