rs2476601 polymorphism in is associated with Crohn's disease but not with ulcerative colitis: a meta-analysis of 16,838 cases and 13,356 controls.

Date publication

janvier 2017

Journal

Annals of gastroenterology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr VUITTON Lucine

Tous les auteurs :
Hedjoudje A, Cheurfa C, Briquez C, Zhang A, Koch S, Vuitton L

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28243041

Résumé

Although the rs2476601 polymorphism of has been reported to be a susceptibility gene for Crohn's disease (CD), results from different studies vary and remain inconclusive. Also, no association has been found between rs2476601 and the risk of ulcerative colitis (UC). The aim of this meta-analysis was to investigate the association between this polymorphism (rs2476601) and the risk of inflammatory bowel disease, UC and CD.

Mots clés

Meta-analysis, PTPN22, candidate gene study, inflammatory bowel disease, polymorphism

Référence

Ann Gastroenterol. 2017 ;30(2):197-208