Increased expression of blood muscarinic receptors in patients with reflex syncope.

Date publication

janvier 2019

Journal

PloS one

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DALI-YOUCEF Nassim , Pr SAULEAU Erik-André , Dr MUTTER Catherine

Tous les auteurs :
Beutelstetter M, Livolsi A, Greney H, Helms P, Schmidt-Mutter C, De Melo C, Roul G, Zores F, Bolle A, Dali-Youcef N, Beaugey M, Simon A, Niederhoffer N, Regnard J, Bouhaddi M, Adamopoulos C, Schaeffer M, Sauleau E, Bousquet P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31318899

Résumé

Pathophysiology of reflex syncope is not fully understood but a vagal overactivity might be involved in this syncope. Previously, overexpression of muscarinic M2 receptors and acetylcholinesterase was found in particular in the heart and in lymphocytes of rabbits with vagal overactivity as well as in hearts of Sudden Infant Death Syndromes. The aim of this present study was to look at M2 receptor expression in blood of patients with reflex syncope. The second objective was to measure acetylcholinesterase expression in these patients.

Référence

PLoS ONE. 2019 ;14(7):e0219598