Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia.

Fiche publication

Date publication

août 2019

Journal

Phytochemistry

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MORJANI Hamid

Tous les auteurs :
Bitchi MB, Magid AA, Kabran FA, Yao-Kouassi PA, Harakat D, Morjani H, Tonzibo FZ, Voutquenne-Nazabadioko L

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31404786

Résumé

Heisteria parvifolia Sm. is prescribed in traditional medecine against numerous diseases in Côte d'Ivoire. Due to the shortcoming in scientifical knowledge of use of this species, our investigations revealed five undescribed cyclopeptide alkaloids added to one known derivative namely anorldianine. These compounds were elucidated by 1D and 2D-NMR experiments and comparison with literature data, and confirmed by HR-ESI-MS. Cytotoxic activity evaluation of these compounds against the chronic myeloid leukemia (K565) cell line exhibited an antiproliferative activity with cell growth inhibition from 13% to 46%.