Mismatch Repair System Deficiency is associated with response to neoadjuvant chemoradiation in locally advanced rectal cancer.

Date publication

août 2019

Journal

International journal of radiation oncology, biology, physics

Auteurs

Membres identifiés du Cancéropôle Est :
Dr VERNEREY Dewi

Tous les auteurs :
Meillan N, Vernerey D, Lefèvre JH, Manceau G, Svrcek M, Augustin J, Fléjou JF, Lascols O, Simon JM, Cohen R, Maingon P, Bachet JB, Huguet F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31404579

Résumé

Defective mismatch repair system (MMR) has been shown to have a favorable impact on outcome in colorectal cancer patients treated with surgery or immunotherapy, adjuvant chemotherapy being discouraged unless there is nodal involvement. Its impact on radiosensitivity is unknown in rectal cancer patients.

Mots clés

MSI, Neoajduvant, chemoradiation, defective mismatch repair system, neoadjuvant treatment, pathological results, rectal cancer, surgery, survival

Référence

Int. J. Radiat. Oncol. Biol. Phys.. 2019 Aug 9;: