Distinct prognostic value of circulating anti-telomerase CD4 Th1 immunity and exhausted PD-1/TIM-3 T cells in lung cancer.

Date publication

juillet 2019

Journal

British journal of cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Pr ADOTEVI Olivier , Pr DE CARVALHO BITTENCOURT Marcelo , Mme JACQUIN Marion , Pr WESTEEL Virginie , Mme LAHEURTE Caroline , Dr VERNEREY Dewi

Tous les auteurs :
Laheurte C, Dosset M, Vernerey D, Boullerot L, Gaugler B, Gravelin E, Kaulek V, Jacquin M, Cuche L, Eberst G, Jacoulet P, Fabre E, Le Pimpec-Barthes F, Tartour E, De Carvalho Bittencourt M, Westeel V, Adotévi O

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31358938

Résumé

Despite the critical roles of Th1-polarised CD4 T cells in cancer immunosurveillance, the translation of their potential to clinical use remains challenging. Here, we investigate the clinical relevance of circulating antitumor Th1 immunity in non-small cell lung cancer (NSCLC).

Référence

Br. J. Cancer. 2019 Jul 30;: