Molecular Profiling Reclassifies Adult Astroblastoma into Known and Clinically Distinct Tumor Entities with Frequent Mitogen-Activated Protein Kinase Pathway Alterations.

Date publication

juillet 2019

Journal

The oncologist

Auteurs

Membres identifiés du Cancéropôle Est :
Pr TAILLANDIER Luc

Tous les auteurs :
Boisseau W, Euskirchen P, Mokhtari K, Dehais C, Touat M, Hoang-Xuan K, Sanson M, Capelle L, Nouet A, Karachi C, Bielle F, Guégan J, Marie Y, Martin-Duverneuil N, Taillandier L, Rousseau A, Delattre JY, Idbaih A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31346129

Résumé

Astroblastoma (ABM) is a rare glial brain tumor. Recurrent meningioma 1 (MN1) alterations have been recently identified in most pediatric cases. Adolescent and adult cases, however, remain molecularly poorly defined.

Mots clés

Astroblastoma, BRAF mutation, MN1‐BEND2, Next‐generation sequencing

Référence

Oncologist. 2019 Jul 25;: