Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression.

Date publication

août 2017

Journal

Journal of the National Cancer Institute

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DAVIDSON Irwin

Tous les auteurs :
Bonet C, Luciani F, Ottavi JF, Leclerc J, Jouenne FM, Boncompagni M, Bille K, Hofman V, Bossis G, Marco de Donatis G, Strub T, Cheli Y, Ohanna M, Luciano F, Marchetti S, Rocchi S, Birling MC, Avril MF, Poulalhon N, Luc T, Hofman P, Lacour JP, Davidson I, Bressac-de Paillerets B, Ballotti R, Marine JC, Bertolotto C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28376192

Résumé

MITF encodes an oncogenic lineage-specific transcription factor in which a germline mutation ( MITFE318K ) was identified in human patients predisposed to both nevus formation and, among other tumor types, melanoma. The molecular mechanisms underlying the oncogenic activity of MITF E318K remained uncharacterized.

Mots clés

Adult, Aged, Animals, Cell Line, Tumor, Cellular Senescence, genetics, Disease Models, Animal, Germ-Line Mutation, Humans, Melanocytes, Melanoma, genetics, Mice, Microphthalmia-Associated Transcription Factor, genetics, Middle Aged, Nevus, genetics, PTEN Phosphohydrolase, genetics, Primary Cell Culture, Proto-Oncogene Proteins B-raf, genetics, Skin Neoplasms, genetics, Sumoylation, Transcriptome

Référence

J. Natl. Cancer Inst.. 2017 08 1;109(8):