Histopathological study of six types of adverse cutaneous drug reactions using granulysin expression.

Date publication

novembre 2016

Journal

International journal of dermatology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CRIBIER Bernard

Tous les auteurs :
Weinborn M, Barbaud A, Truchetet F, Beurey P, Germain L, Cribier B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/27421110

Résumé

Few studies have been published on the histopathology of cutaneous adverse drug reactions (CADR), and most of these lack information on skin allergological tests. The histopathology of drug reaction with eosinophilia and systemic symptoms (DRESS) is also seldom described. The purpose of our study was to examine six types of well-documented CADR (maculopapular exanthema, DRESS, fixed drug eruption, Stevens-Johnson syndrome, toxic epidermal necrolysis [TEN], and acute generalized exanthematous pustulosis) using histopathology and immunohistochemistry to evaluate the expression of granulysin, a key molecule in TEN.

Référence

Int. J. Dermatol.. 2016 Nov;55(11):1225-1233