Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.

Date publication

novembre 2016

Journal

Biochimica et biophysica acta

Auteurs

Membres identifiés du Cancéropôle Est :
Dr EGLY Jean-Marc , Dr LE MAY Nicolas

Tous les auteurs :
Anastasina M, Le May N, Bugai A, Fu Y, Söderholm S, Gaelings L, Ohman T, Tynell J, Kyttänen S, Barboric M, Nyman TA, Matikainen S, Julkunen I, Butcher SJ, Egly JM, Kainov DE

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/27664935

Résumé

Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication.

Référence

Biochim. Biophys. Acta. 2016 Nov;1859(11):1440-1448