Fiche publication
Date publication
novembre 2016
Journal
Molecular psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HAFFEN Emmanuel
,
Pr TROJAK Benoît
Tous les auteurs :
Georgin-Lavialle S, Moura DS, Salvador A, Chauvet-Gelinier JC, Launay JM, Damaj G, Côté F, Soucié E, Chandesris MO, Barète S, Grandpeix-Guyodo C, Bachmeyer C, Alyanakian MA, Aouba A, Lortholary O, Dubreuil P, Teyssier JR, Trojak B, Haffen E, Vandel P, Bonin B, ,Hermine O, Gaillard R
Lien Pubmed
Résumé
Converging sources of evidence point to a role for inflammation in the development of depression, fatigue and cognitive dysfunction. More precisely, the tryptophan (TRP) catabolism is thought to play a major role in inflammation-induced depression. Mastocytosis is a rare disease in which chronic symptoms, including depression, are related to mast cell accumulation and activation. Our objectives were to study the correlations between neuropsychiatric features and the TRP catabolism pathway in mastocytosis in order to demonstrate mast cells' potential involvement in inflammation-induced depression. Fifty-four patients with mastocytosis and a mean age of 50.1 years were enrolled in the study and compared healthy age-matched controls. Depression and stress were evaluated with the Beck Depression Inventory revised and the Perceived Stress Scale. All patients had measurements of TRP, serotonin (5-HT), kynurenine (KYN), indoleamine 2,3-dioxygenase 1 (IDO1) activity (ratio KYN/TRP), kynurenic acid (KA) and quinolinic acid (QA). Patients displayed significantly lower levels of TRP and 5-HT without hypoalbuminemia or malabsorption, higher IDO1 activity, and higher levels of KA and QA, with an imbalance towards the latter. High perceived stress and high depression scores were associated with low TRP and high IDO1 activity. In conclusion, TRP metabolism is altered in mastocytosis and correlates with perceived stress and depression, demonstrating mast cells' involvement in inflammation pathways linked to depression.
Mots clés
Depression, metabolism, Depressive Disorder, Major, metabolism, Female, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Inflammation, metabolism, Kynurenic Acid, Kynurenine, Male, Mast Cells, metabolism, Mastocytosis, metabolism, Middle Aged, Psychiatric Status Rating Scales, Serotonin, Stress, Psychological, Tryptophan, metabolism
Référence
Mol. Psychiatry. 2016 Nov;21(11):1511-1516
