Fiche publication
Date publication
novembre 2016
Journal
Respiratory research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GARRIDO Carmen
,
Dr BELLAYE Pierre-Simon
,
Pr BONNIAUD Philippe
,
Dr BELTRAMO Guillaume
Tous les auteurs :
Burgy O, Bellaye PS, Causse S, Beltramo G, Wettstein G, Boutanquoi PM, Goirand F, Garrido C, Bonniaud P
Lien Pubmed
Résumé
Idiopathic and toxic pulmonary fibrosis are severe diseases starting classically in the subpleural area of the lung. It has recently been suggested that pleural mesothelial cells acquire a myofibroblast phenotype under fibrotic conditions induced by TGF-β1 or bleomycin. The importance and role of inflammation in fibrogenesis are still controversial. In this work, we explored the role of IL-1β/caspase-1 signaling in bleomycin lung toxicity and in pleural mesothelial cell transformation.
Référence
Respir. Res.. 2016 Nov;17(1):162
