Fiche publication
Date publication
novembre 2016
Journal
Bulletin du cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DECOT Véronique
,
Dr POUTHIER Fabienne
Tous les auteurs :
Boulanger F, Decot V, Bulliard G, Calmels B, Giraud C, Lacassagne MN, Magnani A, Pouthier F, Thibert JB, Tirefort Y, Yakoub-Agha I, Baudoux E
Lien Pubmed
Résumé
To date, despite an existing regulatory framework and standards, there are no true technical recommendations. A survey of 23 cell processing facilities (France, Belgium and Switzerland) has allowed to overview current practices according to cellular products specifications upon arrival at the facility, with modalities for their preparation prior to cryopreservation, storage, thawing and finally for infusion to patient. Data analysis shows great variability of collected volumes and cell concentrations in cellular products. Despite homogeneous practices for handling cells at the facility, methods vary between centers, especially for the choice of cryoprotective solutions and thawing methods. During the workshop, practices have been discussed and summarized to write of recommendations about the following topics: processing and cryopreservation, thawing, bedside precautions (for infusion). This work identifies some improvements in terms of collection, choice of wash solution of thawed cells and validation of the conditions of carriage.
Mots clés
Belgium, Cryopreservation, standards, France, Hematopoietic Stem Cell Transplantation, methods, Hematopoietic Stem Cells, Humans, Premedication, methods, Quality Improvement, Societies, Medical, Surveys and Questionnaires, Switzerland
Référence
Bull Cancer. 2016 Nov;103(11S):S267-S272
