Fiche publication
Date publication
octobre 2016
Journal
Clinical rheumatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr JOUZEAU Jean-Yves
Tous les auteurs :
Latar I, Koufany M, Hablot J, Loeuille D, Netter P, Jouzeau JY, Chary-Valckenaere I, Moulin D
Lien Pubmed
Résumé
Classically, mast cells (MC) are considered as important actors of the innate immune response playing a pivotal role in IgE-mediated allergic and antiparasite responses. In the last two decades, many experimental evidences demonstrated that these hematopoietic-derived cells present in both connective and mucosal tissues are also key modulators of the adaptive immune response and could contribute to autoimmune disease notably in rheumatoid arthritis (RA). Recently, Bader-Meunier et al. reported a series of 31 patients suffering from inflammatory joint diseases associated with mastocytosis, suggesting that mastocytosis was associated with a higher prevalence in spondyloarthritis. We discuss here the possible link between chronic inflammatory arthritis and mastocytosis through the report of a clinical case describing a patient developing RA after a long history of mastocytosis. Of great interest, antihistamine treatment alone was sufficient to treat RA in this patient.
Mots clés
Aged, Arthritis, Rheumatoid, complications, Histamine Antagonists, therapeutic use, Humans, Male, Mastocytosis, Systemic, complications
Référence
Clin. Rheumatol.. 2016 Oct;35(10):2619-23
