Superparamagnetic Nanoparticle Delivery to the Cochlea Through Round Window by External Magnetic Field: Feasibility and Toxicity.

Fiche publication

Date publication

septembre 2019

Journal

Surgical innovation

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MILLOT Nadine , Dr COLLIN Bertrand , Dr BOUDON Julien

Tous les auteurs :
Leterme G, Guigou C, Oudot A, Collin B, Boudon J, Millot N, Geissler A, Belharet K, Bozorg Grayeli A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31478462

Résumé

. The objective of this study was to evaluate the feasibility and toxicity of superparamagnetic iron oxide nanoparticles (SPIONs) administered into the cochlea through the round window (RW) by an external magnetic field. . In 5 Wistar rats, the left RW was punctured. SPIONs suspended in hyaluronic gel (5 mg/mL) were applied in the RW niche and covered by a muscle graft. The nanoparticles were mobilized using a rare earth magnet (0.54 T) held in 4 consecutive positions around the head. The right ear served as control. Hearing function was monitored by auditory brainstem responses (4-32 kHz tone bursts). . The auditory thresholds remained unchanged 1 month after the administration. The histological study of the cochleae showed that SPIONs were driven into the in the basal turn, the second turn, and the apex. . Superparamagnetic nanoparticles can be driven inside the cochlea toward the apex with a preserved hearing up to 1 month in rats.