Fiche publication
Date publication
septembre 2019
Journal
Nutrients
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DELMAS Dominique
,
Pr LATRUFFE Norbert
,
Dr AIRES Virginie
Tous les auteurs :
Aires V, Colin DJ, Doreau A, Di Pietro A, Heydel JM, Artur Y, Latruffe N, Delmas D
Lien Pubmed
Résumé
Resveratrol has been proposed to prevent tumor growth and the different steps of carcinogenesis; nevertheless, these biological effects are sometimes discordant between different cell types. Several hypotheses and works have suggested that the metabolism of resveratrol could be at the origin of a different cellular response. We show here, using colorectal tumor cell lines, that the biological effects of RSV result mainly from its carriage by carriers of the superfamily of ABC transporter, i.e., P-gP, MRP, or BCRP. Using cell lines overexpressing these different transporters, we have been able to highlight the importance of P-gP in the response of cells to RSV. These results were confirmed by invalidating the gene coding for P-gP, which restored the sensitivity of colorectal cells resistant to the polyphenol. Subsequently, the status of P-glycoprotein expression is an important element to be taken into consideration in the cytotoxic activity of resveratrol in colorectal cancer cells.
Mots clés
ABC transporters, colon cancer, resveratrol, sensitivity, transport
Référence
Nutrients. 2019 Sep 4;11(9):
