Fiche publication
Date publication
octobre 2016
Journal
Planta medica
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie
,
Dr NUZILLARD Jean-Marc
Tous les auteurs :
Hubert J, Angelis A, Aligiannis N, Rosalia M, Abedini A, Bakiri A, Reynaud R, Nuzillard JM, Gangloff SC, Skaltsounis AL, Renault JH
Lien Pubmed
Résumé
Wood residues produced from forestry activities represent an interesting source of biologically active, high value-added secondary metabolites. In this study, 30 extracts from 10 barks of deciduous and coniferous tree species were investigated for their potential dermo-cosmetic use. The extracts were obtained from Fagus sylvatica, Quercus robur, Alnus glutinosa, Prunus avium, Acer pseudoplatanus, Fraxinus excelsior, Populus robusta, Larix decidua, Picea abies, and Populus tremula after three successive solid/liquid extractions of the barks with n-heptane, methanol, and methanol/water. All extracts were evaluated for their radical scavenging capacity, for their elastase, collagenase, and tyrosinase inhibitory activities, as well as for their antibacterial activity against gram-positive Staphylococcus aureus. In parallel, the global metabolite profiles of all extracts were established by 1D and 2D NMR and related to their biological activity. The results showed that the methanol extracts of Q. robur, A. glutinosa, L. decidua, and P. abies barks exhibit particularly high activities on most bioassays, suggesting their promising use as active ingredients in the dermo-cosmetic industry.
Mots clés
Animals, Anti-Bacterial Agents, pharmacology, Dermatologic Agents, chemistry, Drug Evaluation, Preclinical, methods, Enzyme Inhibitors, chemistry, Magnetic Resonance Spectroscopy, Monophenol Monooxygenase, antagonists & inhibitors, Pancreatic Elastase, antagonists & inhibitors, Plant Bark, chemistry, Plant Extracts, chemistry, Staphylococcus aureus, drug effects, Trees, chemistry
Référence
Planta Med.. 2016 Oct;82(15):1351-1358
