WntD and Diedel: Two immunomodulatory cytokines in Drosophila immunity.

Date publication

octobre 2016

Journal

Fly

Auteurs

Membres identifiés du Cancéropôle Est :
Pr IMLER Jean-Luc , Dr MEIGNIN Carine

Tous les auteurs :
Lamiable O, Meignin C, Imler JL

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/27314646

Résumé

Remarkable progress has been made on the understanding of the basic mechanisms of innate immunity in flies, from sensing infection to production of effector molecules. However, how the immune response is orchestrated at the level of the organism remains poorly understood. While cytokines activating immune responses, such as Spaetzle or Unpaired-3, have been identified and characterized in Drosophila, much less is known regarding immunosuppressor cytokines. In a recent publication, we reported the identification of a novel cytokine, Diedel, which acts as systemic negative regulator of the IMD pathway. Here, we discuss the similarities between Diedel and WntD, another immunomodulatory cytokine and present evidence that the 2 molecules act independently from one another.

Mots clés

Adaptor Proteins, Signal Transducing, metabolism, Animals, Antigens, Differentiation, metabolism, Cytokines, immunology, Drosophila Proteins, immunology, Drosophila melanogaster, immunology, Immunity, Innate, Intracellular Signaling Peptides and Proteins, immunology, Receptors, Immunologic, metabolism

Référence

Fly (Austin). 2016 10;10(4):187-94