Fiche publication
Date publication
octobre 2016
Journal
Phytochemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DUCA Laurent
Tous les auteurs :
Zebiri I, Haddad M, Duca L, Harakat D, Cabanillas B, Paloque L, Scandolera A, Sauvain M, Rengifo E, Voutquenne-Nazabadioko L
Lien Pubmed
Résumé
Twelve oleanane saponins, zebiriosides A-L, were isolated from the roots of Dendrobangia boliviana Rusby, together with two known saponins, talunùmoside I and 3-O-β-d-glucuronopyranosyl serjanic acid. These saponins are glycosides of serjanic or phytolaccinic acid. Their structures were established on two basis: first, their spectral data, mainly HR-TOFESIMS, 1D-NMR ((1)H, (13)C, DEPT) and 2D-NMR ((1)H(1)H COSY, TOCSY, HSQC, HMBC, and ROESY), and second by comparison with literature data. These compounds were evaluated for their cytotoxic, antileishmanial and hemolytic activities. No antileishmanial or hemolytic activities were revealed, however zebirioside C and zebirioside I showed cytotoxicity against fibroblasts with IC50 of 6.4 and 5.6 μM, respectively.
Mots clés
Angiosperms, chemistry, Antineoplastic Agents, Phytogenic, chemistry, Cytotoxins, chemistry, Fibroblasts, drug effects, Leishmania, drug effects, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Oleanolic Acid, analogs & derivatives, Plant Roots, chemistry, Saponins, chemistry, Triterpenes, chemistry
Référence
Phytochemistry. 2016 Oct;130:262-72
