Fiche publication


Date publication

septembre 2019

Journal

Autoimmunity reviews

Auteurs

Membres identifiés du Cancéropôle Est :
Dr VUITTON Lucine


Tous les auteurs :
Jamilloux Y, El Jammal T, Vuitton L, Gerfaud-Valentin M, Kerever S, Sève P

Résumé

Cytokines play a central role in the pathophysiology of autoimmune and inflammatory diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized as a major target to inhibit the effect of a wide array of cytokines. JAK inhibitors are increasingly used in the setting of inflammatory and autoimmune diseases. While the currently approved drugs are panJAK inhibitors, more selective small molecules are being developed and tested in various rheumatic disorders. In this extensive review, we present evidence- or hypothesis-based perspectives for these drugs in various rheumatologic conditions, such as rheumatoid arthritis, systemic lupus erythematosus, giant cell arteritis, and autoinflammatory diseases.

Mots clés

Autoimmune disease, JAK inhibitor, Psoriatic arthritis, Rheumatoid arthritis, Tofacitinib

Référence

Autoimmun Rev. 2019 Sep 11;:102390