Staphylococcus aureus RNAIII and Its Regulon Link Quorum Sensing, Stress Responses, Metabolic Adaptation, and Regulation of Virulence Gene Expression.

Date publication

septembre 2016

Journal

Annual review of microbiology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr ROMBY Pascale

Tous les auteurs :
Bronesky D, Wu Z, Marzi S, Walter P, Geissmann T, Moreau K, Vandenesch F, Caldelari I, Romby P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/27482744

Résumé

Staphylococcus aureus RNAIII is one of the main intracellular effectors of the quorum-sensing system. It is a multifunctional RNA that encodes a small peptide, and its noncoding parts act as antisense RNAs to regulate the translation and/or the stability of mRNAs encoding transcriptional regulators, major virulence factors, and cell wall metabolism enzymes. In this review, we explain how regulatory proteins and RNAIII are embedded in complex regulatory circuits to express virulence factors in a dynamic and timely manner in response to stress and environmental and metabolic changes.

Mots clés

Animals, Bacterial Proteins, Gene Expression Regulation, Bacterial, Humans, Quorum Sensing, RNA, Bacterial, genetics, Regulon, Staphylococcal Infections, microbiology, Staphylococcus aureus, enzymology, Virulence, Virulence Factors, genetics

Référence

Annu. Rev. Microbiol.. 2016 09 8;70:299-316