Fiche publication
Date publication
septembre 2019
Journal
International journal of molecular sciences
Lien Pubmed
Résumé
Heat shock proteins (HSP) regulate inflammation in many physiological contexts. However, inflammation is a broad process, involving numerous cytokines produced by different molecular pathways with multiple functions. In this review, we focused on the particular role of HSP on the inflammasomes intracellular platforms activated by danger signals and that enable activation of inflammatory caspases, mainly caspase-1, leading to the production of the pro-inflammatory cytokine IL-1β. Interestingly, some members of the HSP family favor inflammasomes activation whereas others inhibit it, suggesting that HSP modulators for therapeutic purposes, must be carefully chosen.
Mots clés
IL-1β, caspase-1, heat shock proteins, inflammasomes
Référence
Int J Mol Sci. 2019 Sep 12;20(18):
