Fiche publication
Date publication
septembre 2016
Journal
Trends in biochemical sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Dr YUSUPOV Marat
,
Dr YUSUPOVA Gulnara
Tous les auteurs :
Rozov A, Demeshkina N, Westhof E, Yusupov M, Yusupova G
Lien Pubmed
Résumé
The fidelity of translation depends strongly on the selection of the correct aminoacyl-tRNA that is complementary to the mRNA codon present in the ribosomal decoding center. The ribosome occasionally makes mistakes by selecting the wrong substrate from the pool of aminoacyl-tRNAs. Here, we summarize recent structural advances that may help to clarify the origin of missense errors that occur during decoding. These developments suggest that discrimination between tRNAs is based primarily on steric complementarity and shape acceptance rather than on the number of hydrogen bonds between the molding of the decoding center and the codon-anticodon duplex. They strengthen the hypothesis that spatial mimicry, due either to base tautomerism or ionization, drives infidelity in ribosomal translation.
Mots clés
Anticodon, genetics, Codon, genetics, Genetic Code, genetics, Hydrogen Bonding, Mutation, Missense, genetics, Protein Biosynthesis, genetics, RNA, Transfer, Amino Acid-Specific, chemistry, Ribosomes, chemistry
Référence
Trends Biochem. Sci.. 2016 09;41(9):798-814
