Fiche publication
Date publication
avril 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr JOUZEAU Jean-Yves
Tous les auteurs :
Trechot P, Jouzeau JY
Résumé
Non-steroidal anti-inflammatory drugs (NSAIDs) are used frequently in daily practice. Two iso-enzymes of prostaglandin-H synthase (PGHS) have been isolated. PGHS-1 (COX-1) is above all involved in the mechanism of homeostasis whereas PGHS-2 (COX-2) is mainly expressed during an inflammatory reaction. NSAIDs classically inhibit the biosynthesis of prostaglandins with different effects, depending on the involvement of each of the two PGHS iso-enzymes. When compared, all NSAID inhibitors selective for COX-2 (coxibs) do not have the same degree of coxib selectivity, and some drugs are much too selective for COX-2. It has been shown that their use was associated with an increased cardiovascular risk. Rofecoxib was withdrawn from the market and other coxibs have been contra-indicated for patients with established cardiovascular disease. Different classifications of NSAIDs are possible, among which is one based on the concept of generation and the other on its chemical structure. (C) 2014 Elsevier Masson SAS. All rights reserved.
Référence
Rev Fr Allergol. 2014 Apr;54(3):212-7.
