Automated and efficient radiosynthesis of [(18)F]FLT using a low amount of precursor.

Date publication

août 2016

Journal

Nuclear medicine and biology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BRASSE David , Pr LAQUERRIERE Patrice

Tous les auteurs :
Marchand P, Ouadi A, Pellicioli M, Schuler J, Laquerriere P, Boisson F, Brasse D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/27314451

Résumé

Since 1991 until now, many radiosyntheses of [(18)F]FLT have been published. Most of them suffer from side reactions and/or difficult purification related to the large amount of precursor necessary for the labeling step. A fully automated synthesis using only commercial and unmodified materials with a reduced amount of precursor would be desirable.

Référence

Nucl. Med. Biol.. 2016 Aug;43(8):520-7