Fiche publication
Date publication
août 2016
Journal
Atherosclerosis
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LAGROST Laurent
,
Pr MARTIN Laurent
,
Pr PETIT Jean-Michel
,
Mme TRUNTZER Caroline
,
Dr PAIS DE BARROS Jean-Paul
,
Pr MASSON David
Tous les auteurs :
Ménégaut L, Masson D, Abello N, Denimal D, Truntzer C, Ducoroy P, Lagrost L, Pais de Barros JP, Athias A, Petit JM, Martin L, Steinmetz E, Kretz B
Lien Pubmed
Résumé
Diabetic patients are at high risk of stroke and coronary artery disease. Recent data suggest that arachidonic acid metabolism is altered in diabetic conditions and that these alterations contribute to accelerated atherosclerosis. Little is known about how these alterations affect the metabolism and the proportions of different lipid species within the atherosclerotic plaque. The aim of our study was to perform a targeted lipidomic analysis of human atherosclerotic lesions, with a specific focus on PUFA-containing lipid species, to reveal differences in the fatty-acid composition of plaque in diabetic patients compared with non-diabetic controls.
Référence
Atherosclerosis. 2016 Aug;251:339-47
