The anti-fibrotic role of mast cells in the liver is mediated by HLA-G and interaction with hepatic stellate cells.

Fiche publication

Date publication

mai 2019

Journal

Cytokine

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DRENOU Bernard

Tous les auteurs :
Amiot L, Vu N, Drenou B, Scrofani M, Chalin A, Devisme C, Samson M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30825834

Résumé

We have reported a significant association between HLA-G expression or the number of hepatic mast cells and liver fibrosis. Here, we investigated the role of HLA-G and mast cells in liver fibrosis, focusing, in particular, on interactions between human mast and stellate cells.