The donor-acceptor biphenyl platform: a versatile chromophore for the engineering of highly efficient two-photon sensitive photoremovable protecting groups.

Fiche publication

Date publication

mars 2012

Journal

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr SPECHT Alexandre

Tous les auteurs :
Specht A, Bolze F, Donato L, Herbivo C, Charon S, Warther D, Gug S, Nicoud JF, Goeldner M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/22322902

Résumé

Different photoremovable protecting groups in the o-nitrobenzyl, phenacyl, and 2-(o-nitrophenyl)propyl series with a donor-acceptor biphenyl backbone, known to display excellent two-photon absorption cross-sections, were investigated in order to develop efficient two-photon sensitive photoremovable protecting groups. The 2-(o-nitrophenyl)propyl series was a more versatile platform to increase the two-photon sensitivity of photoremovable protecting groups, leading to the p-alkoxy and p-bisalkylamino-4-nitro-[1,1'-biphenyl]-3-yl)propyl derivatives: PENB and EANBP respectively. Those two photoremovable protecting groups are to date the best caging groups for two-photon excitation at 800 and 740 nm respectively, offering attracting perspectives in chemical biology.