Expression of the semicarbazide-sensitive amine oxidase in articular cartilage: its role in terminal differentiation of chondrocytes in rat and human.

Date publication

juillet 2016

Journal

Osteoarthritis and cartilage

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GILLET Pierre , Pr MAGDALOU Jacques , Pr MAINARD Didier

Tous les auteurs :
Filip A, Pinzano A, Bianchi A, Fève B, Jalkanen S, Gillet P, Mainard D, Lacolley P, Magdalou J, Mercier N

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26851450

Résumé

Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the oxidation of primary amines into ammonia and reactive species (hydrogen peroxide, aldehydes). It is highly expressed in mammalian tissues, especially in vascular smooth muscle cells and adipocytes, where it plays a role in cell differentiation and glucose transport. The study aims at characterizing the expression and the activity of SSAO in rat and human articular cartilage of the knee, and to investigate its potential role in chondrocyte terminal differentiation.

Référence

Osteoarthr. Cartil.. 2016 Jul;24(7):1223-34