Fiche publication
Date publication
juin 2016
Journal
Journal of thrombosis and haemostasis : JTH
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GACHET Christian
Tous les auteurs :
Antkowiak A, Viaud J, Severin S, Zanoun M, Ceccato L, Chicanne G, Strassel C, Eckly A, Leon C, Gachet C, Payrastre B, Gaits-Iacovoni F
Lien Pubmed
Résumé
Essentials Information about the formation of the demarcation membrane system (DMS) is still lacking. We investigated the role of the cytoskeleton in DMS structuration in megakaryocytes. Cdc42/Pak-dependent F-actin remodeling regulates DMS organization for proper megakaryopoiesis. These data highlight the mandatory role of F-actin in platelet biogenesis.
Mots clés
Actins, metabolism, Animals, Blood Platelets, metabolism, Cell Differentiation, Cell Line, Tumor, Cell Membrane, metabolism, Cytoskeleton, metabolism, Fluorescence Resonance Energy Transfer, Humans, Imaging, Three-Dimensional, Lentivirus, Megakaryocytes, metabolism, Mice, Mice, Inbred C57BL, Microscopy, Confocal, Microscopy, Electron, Transmission, Signal Transduction, Thrombopoiesis, cdc42 GTP-Binding Protein, chemistry, p21-Activated Kinases, metabolism
Référence
J. Thromb. Haemost.. 2016 06;14(6):1268-84
