Persistence of lymphocyte function perturbations after granulocyte-colony-stimulating factor mobilization and cytapheresis in normal peripheral blood stem cell donors.

Date publication

décembre 2010

Journal

Transfusion

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DECONINCK Eric , Dr LAROSA Fabrice , Dr POUTHIER Fabienne

Tous les auteurs :
Marmier-Savet C, Larosa F, Legrand F, Witz B, Michallet M, Ranta D, Louvat P, Puyraveau M, Raus N, Tavernier M, Mathieu-Nafissi S, Hequet O, Pouthier F, Deconinck E, Tiberghien P, Robinet E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/20663114

Résumé

The short-term effects of granulocyte-colony-stimulating factor (G-CSF) have been extensively studied, but recent reports of G-CSF-induced genetic perturbations raised concerns regarding its long-term safety. In this respect, duration of G-CSF-induced perturbations has been less studied than short-term effects and needs to be evaluated.

Mots clés

Adult, Blood Donors, Cell Movement, drug effects, Female, Follow-Up Studies, Granulocyte Colony-Stimulating Factor, adverse effects, Hematopoietic Stem Cell Mobilization, adverse effects, Hematopoietic Stem Cells, drug effects, Humans, Immune System Diseases, blood, Leukapheresis, methods, Lymphocytes, drug effects, Male, Middle Aged, Recombinant Proteins, Recovery of Function, immunology, Time Factors, Young Adult

Référence

Transfusion. 2010 Dec;50(12):2676-85