Fiche publication
Date publication
octobre 2019
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOETZ Jacky
Tous les auteurs :
San Juan BP, Garcia-Leon MJ, Rangel L, Goetz JG, Chaffer CL
Lien Pubmed
Résumé
Therapies that prevent metastatic dissemination and tumor growth in secondary organs are severely lacking. A better understanding of the mechanisms that drive metastasis will lead to improved therapies that increase patient survival. Within a tumor, cancer cells are equipped with different phenotypic and functional capacities that can impact their ability to complete the metastatic cascade. That phenotypic heterogeneity can be derived from a combination of factors, in which the genetic make-up, interaction with the environment, and ability of cells to adapt to evolving microenvironments and mechanical forces play a major role. In this review, we discuss the specific properties of those cancer cell subgroups and the mechanisms that confer or restrict their capacity to metastasize.
Mots clés
CTC-clusters, biomechanics, circulating tumor cells (CTCs), extracellular vesicles, epigenetics, epithelial-to-mesenchymal transition, heterogeneity, metastasis, metastatic niche, plasticity
Référence
Cancers (Basel). 2019 Oct 16;11(10):
