A hierarchical approach in the diagnostic workflow of chronic myelomonocytic leukemia: Pivotal role of the "Mono-dysplasia-score" combined with flow cytometric quantification of monocyte subsets.

Fiche publication

Date publication

octobre 2019

Journal

International journal of laboratory hematology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GARNACHE-OTTOU Francine

Tous les auteurs :
Zhu J, Sourdeau E, Aubert H, Clauser S, Maillon A, Capron C, Jondeau K, Ronez E, Schillinger F, Garnache-Ottou F, Cornet E, Bardet V

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31647610

Résumé

Monocytosis is a frequent trigger for blood smear review in a routine hematology laboratory whereas chronic myelomonocytic leukemia (CMML) is infrequent and arises mostly in elderly patients. In order to define the best workflow for monocytosis, we studied three diagnostic approaches: the classical morphology approach (blood smear review), the flow cytometry assay (quantification of monocyte subsets as described by Selimoglu-Buet et al in 2015), and the "mono-dysplasia-score" also referred to as "Monoscore (as described by our team in 2018 using the structural parameters of the Sysmex XN™ analyzers).