Constitutive or Induced HIF-2 Addiction is Involved in Resistance to Anti-EGFR Treatment and Radiation Therapy in HNSCC.

Date publication

octobre 2019

Journal

Cancers

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GAIDDON Christian , Dr JUNG Alain , Dr PENCREACH Erwan , Dr COLIAT Pierre

Tous les auteurs :
Coliat P, Ramolu L, Jégu J, Gaiddon C, Jung AC, Pencreach E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31640284

Résumé

management of head and neck squamous cell carcinomas (HNSCC) include anti-Epidermal Growth Factor Receptor (EGFR) antibodies and radiotherapy, but resistance emerges in most patients. mutations lead to primary resistance to EGFR blockade in metastatic colorectal cancer but are infrequent in HNSCC, suggesting that other mechanisms are implicated. Since hypoxia and Hypoxia Inducible Factor-1 (HIF-1) have been associated with treatment failure and tumor progression, we hypothesized that EGFR/mammalian Target Of Rapamycin (mTOR)/HIF-1 axis inhibition could radiosensitize HNSCC.

Mots clés

HIF-2α, anti-EGFR targeted therapy, head and neck squamous cell carcinoma, oncogenic addiction, resistance

Référence

Cancers (Basel). 2019 Oct 21;11(10):