A fluorogenic BODIPY molecular rotor as an apoptosis marker.

Date publication

juin 2019

Journal

Chemical communications (Cambridge, England)

Auteurs

Membres identifiés du Cancéropôle Est :
Dr KLYMCHENKO Andrey

Tous les auteurs :
Ashokkumar P, Ashoka AH, Collot M, Das A, Klymchenko AS

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31134979

Résumé

Based on a BODIPY molecular rotor and a zinc-dipicolylamine receptor, we designed a fluorogenic probe for the detection of apoptosis. Being poorly emissive in solution and with healthy cells, it selectively binds phosphatidylserine of early apoptotic cells and internalizes into late apoptotic cells, lighting up its green fluorescence.

Mots clés

Apoptosis, Biomarkers, Tumor, analysis, Boron Compounds, chemistry, Cell Line, Cell Membrane, metabolism, Fluorescent Dyes, chemistry, HeLa Cells, Humans, Organometallic Compounds, analysis, Phosphatidylserines, chemistry, Picolinic Acids, analysis

Référence

Chem. Commun. (Camb.). 2019 Jun 11;55(48):6902-6905