Visualising the membrane viscosity of porcine eye lens cells using molecular rotors.

Date publication

mai 2017

Journal

Chemical science

Auteurs

Membres identifiés du Cancéropôle Est :
Dr KLYMCHENKO Andrey

Tous les auteurs :
Sherin PS, López-Duarte I, Dent MR, Kubánková M, Vyšniauskas A, Bull JA, Reshetnikova ES, Klymchenko AS, Tsentalovich YP, Kuimova MK

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28580097

Résumé

The plasma membranes of cells within the eye lens play an important role in metabolite transport within the avascular tissue of the lens, maintaining its transparency over the entire lifespan of an individual. Here we use viscosity-sensitive 'molecular rotors' to map the microscopic viscosity within these unusual cell membranes, establishing that they are characterised by an unprecedentedly high degree of lipid organisation.

Référence

Chem Sci. 2017 May 1;8(5):3523-3528