SIRT1 activation rescues the mislocalization of RNA-binding proteins and cognitive defects induced by inherited cobalamin disorders.

Date publication

octobre 2019

Journal

Metabolism: clinical and experimental

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis , Dr BATTAGLIA-HSU Shyue-Fang , Dr DREUMONT Natacha

Tous les auteurs :
Ghemrawi R, Arnold C, Battaglia-Hsu SF, Pourié G, Trinh I, Bassila C, Charif R, Wiedemann A, Flayac J, Robert A, Dreumont N, Feillet F, Guéant JL, Coelho D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31672445

Résumé

The molecular consequences of inborn errors of vitamin B12 or cobalamin metabolism are far from being understood. Moreover, innovative therapeutic strategies are needed for the treatment of neurological outcomes that are usually resistant to conventional treatments. Our previous findings suggest a link between SIRT1, cellular stress and RNA binding proteins (RBP) mislocalization in the pathological mechanisms triggered by impaired vitamin B12 metabolism.

Mots clés

Cognitive defect, Inherited defect, RNA binding protein, SIRT1, SRT1720, Vitamin B12

Référence

Metab. Clin. Exp.. 2019 Oct 28;:153992