Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects.

Fiche publication

Date publication

novembre 2019

Journal

Journal of experimental & clinical cancer research : CR

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DESAUBRY Laurent

Tous les auteurs :
Bentayeb H, Aitamer M, Petit B, Dubanet L, Elderwish S, Désaubry L, de Gramont A, Raymond E, Olivrie A, Abraham J, Jauberteau MO, Troutaud D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31684984

Résumé

Diffuse large B-cell lymphomas (DLBCLs) are aggressive lymphomas accounting for approximately a third of non-Hodgkin lymphomas. Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are scaffold proteins that promote mitochondria homeostasis and consequently cell survival, but biological functions of cytoplasmic PHBs remain largely unknown in DLBCL.