Ageing enhances the shedding of splenocyte microvesicles with endothelial pro-senescent effect that is prevented by a short-term intake of omega-3 PUFA EPA:DHA 6:1.

Date publication

décembre 2019

Journal

Biochemical pharmacology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie , Dr AUGER Cyril

Tous les auteurs :
Qureshi AW, Altamimy R, El Habhab A, El Itawi H, Farooq MA, Zobairi F, Hasan H, Amoura L, Auger C, Schini-Kerth V, Toti F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31811867

Résumé

Ageing is associated with progressive endothelial senescence and dysfunction, and cardiovascular risk. Circulating endothelial microvesicles (MVs) are pro-senescent and pro-inflammatory endothelial effectors in acute coronary syndrome. Omega 3 PUFAs intake was claimed beneficial in cardiovascular prevention.

Mots clés

Microparticles, angiotensin system, endothelial senescence, omega-3 polyunsaturated fatty acids, oxidative stress, spleen leukocyte

Référence

Biochem. Pharmacol.. 2019 Dec 4;:113734