Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric -Mutated Gliomas Recreate the Patient Tumor Complexity.

Date publication

novembre 2019

Journal

Cancers

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DONTENWILL Monique , Pr ENTZ-WERLE Natacha , Dr GUENOT Dominique , Dr GUERIN Eric , Pr NAMER Izzie-Jacques , Dr VILLA Pascal , Dr LHERMITTE Benoît , Dr REITA Damien

Tous les auteurs :
Blandin AF, Durand A, Litzler M, Tripp A, Guérin É, Ruhland E, Obrecht A, Keime C, Fuchs Q, Reita D, Lhermitte B, Coca A, Jones C, Rebel IL, Villa P, Namer IJ, Dontenwill M, Guenot D, Entz-Werle N

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31779235

Résumé

Pediatric high-grade gliomas (pHGGs) are facing a very dismal prognosis and representative pre-clinical models are needed for new treatment strategies. Here, we examined the relevance of collecting functional, genomic, and metabolomics data to validate patient-derived models in a hypoxic microenvironment.

Mots clés

hypoxia, intra-tumor heterogeneity, models, pediatric high-grade glioma, tumor and cell metabolism

Référence

Cancers (Basel). 2019 Nov 26;11(12):