Reconstruction of gene regulatory networks reveals chromatin remodelers and key transcription factors in tumorigenesis.

Date publication

mai 2016

Journal

Genome medicine

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GRONEMEYER Hinrich , Dr MENDOZA Manuel

Tous les auteurs :
Malysheva V, Mendoza-Parra MA, Saleem MA, Gronemeyer H

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/27198694

Résumé

Alterations in genetic and epigenetic landscapes are known to contribute to the development of different types of cancer. However, the mechanistic links between transcription factors and the epigenome which coordinate the deregulation of gene networks during cell transformation are largely unknown.

Mots clés

Cell Line, Cell Transformation, Neoplastic, genetics, Chromatin Assembly and Disassembly, Gene Expression Profiling, methods, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Humans, Sequence Analysis, RNA, methods, Transcription Factors, genetics

Référence

Genome Med. 2016 05;8(1):57