Standardization of a well-controlled in vivo mouse model of thrombus formation induced by mechanical injury.

Date publication

mai 2016

Journal

Thrombosis research

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GACHET Christian

Tous les auteurs :
Tang C, Wang Y, Lei D, Huang L, Wang G, Chi Q, Zheng Y, Gachet C, Mangin PH, Zhu L

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26967532

Résumé

Vascular plug formation by mechanical injury that exposes abundant extracellular matrix is an ideal model to mimic thrombus formation. The objective of this study was to standardize our previously established in vivo mouse model of thrombus formation induced by mechanical injury.

Mots clés

Animals, Aorta, drug effects, Disease Models, Animal, Endothelium, Vascular, drug effects, Hirudin Therapy, methods, Male, Mice, Mice, Inbred C57BL, Peptides, therapeutic use, Platelet Aggregation Inhibitors, therapeutic use, Platelet Glycoprotein GPIIb-IIIa Complex, antagonists & inhibitors, Stress, Mechanical, Thrombosis, drug therapy, Ticlopidine, analogs & derivatives

Référence

Thromb. Res.. 2016 May;141:49-57