Mesenchymal Stem/Stromal Cell Production Compliant with Good Manufacturing Practice: Comparison between Bone Marrow, the Gold Standard Adult Source, and Wharton's Jelly, an Extraembryonic Source.

Fiche publication

Date publication

décembre 2019

Journal

Journal of clinical medicine

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BENSOUSSAN Danièle , Pr DECOT Véronique , Dr REPPEL Loïc

Tous les auteurs :
Laroye C, Gauthier M, Antonot H, Decot V, Reppel L, Bensoussan D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31847319

Résumé

Many clinical trials report mesenchymal stem/stromal cells (MSCs) efficacy in various indications. Therefore, standardization of MSC production becomes necessary. MSC properties are impacted by tissue origin, especially if they are from extraembryonic tissue or adult sources. For this reason, we evaluated the impact of MSC tissue origin on production.