Identification of Specific Tumor Markers in Vulvar Carcinoma Through Extensive Human Papillomavirus DNA Characterization Using Next Generation Sequencing Method.

Date publication

janvier 2020

Journal

Journal of lower genital tract disease

Auteurs

Membres identifiés du Cancéropôle Est :
Pr HARLE Alexandre , Dr LEROUX Agnès , Pr MARCHAL Frédéric , Pr MERLIN Jean-Louis , Dr LEUFFLEN Léa

Tous les auteurs :
Thomas J, Leufflen L, Chesnais V, Diry S, Demange J, Depardieu C, Bani MA, Marchal F, Charra-Brunaud C, Merlin JL, Leroux A, Sastre-Garau X, Harlé A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31860576

Résumé

A subset of vulvar carcinomas (VC) are associated with human papillomavirus (HPV) DNA. This trait can be used to identify tumor markers for patient's follow-up. A large diversity of HPV prevalence in VC has been reported, but no data are available concerning the insertional HPV status in this tumor type. Therefore, we have used an innovative next generation sequencing (NGS)-based CaptHPV method able to provide an extensive characterization of HPV DNA in tumors.

Référence

J Low Genit Tract Dis. 2020 Jan;24(1):53-60