Ortho-Functionalized Aryltetrazines by Direct Palladium-Catalyzed C-H Halogenation: Application to Fast Electrophilic Fluorination Reactions.

Date publication

avril 2016

Journal

Angewandte Chemie (International ed. in English)

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DECREAU Richard

Tous les auteurs :
Testa C, Gigot É, Genc S, Decréau R, Roger J, Hierso JC

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/27010438

Résumé

A general catalyzed direct C-H functionalization of s-tetrazines is reported. Under mild reaction conditions, N-directed ortho-C-H activation of tetrazines allows the introduction of various functional groups, thus forming carbon-heteroatom bonds: C-X (X=I, Br, Cl) and C-O. Based on this methodology, we developed electrophilic mono- and poly-ortho-fluorination of tetrazines. Microwave irradiation was optimized to afford fluorinated s-aryltetrazines, with satisfactory selectivity, within only ten minutes. This work provides an efficient and practical entry for further accessing highly substituted tetrazine derivatives (iodo, bromo, chloro, fluoro, and acetate precursors). It gives access to ortho-functionalized aryltetrazines which are difficult to obtain by classical Pinner-like syntheses.

Référence

Angew. Chem. Int. Ed. Engl.. 2016 Apr;55(18):5555-9