Fiche publication
Date publication
janvier 2020
Journal
Allergy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis
,
Dr OUSSALAH Abderrahim
Tous les auteurs :
Oussalah A, Yip V, Mayorga C, Blanca M, Barbaud A, Nakonechna A, Cernadas J, Gotua M, Brockow K, Caubet JC, Bircher A, Atanaskovic-Markovic M, Demoly P, Kase-Tanno L, Terreehorst I, Laguna JJ, Romano A, Guéant JL, Munir P,
Lien Pubmed
Résumé
Drug hypersensitivity reactions (DHRs) are associated with high global morbidity and mortality. Cutaneous T cell-mediated reactions classically occur more than 6 hours after drug administration and include life-threatening conditions such as toxic epidermal necrolysis, Stevens-Johnson syndrome, and hypersensitivity syndrome. Over the last 20 years, significant advances have been made in our understanding of the pathogenesis of DHRs with the identification of human leukocyte antigens as predisposing factors. This has led to the development of pharmacogenetic screening tests, such as HLA-B*57:01 in abacavir therapy, which has successfully reduced the incidence of abacavir hypersensitivity reactions. We have completed a PRISMA-compliant systematic review to identify genetic associations that have been reported in DHRs. In total, 105 studies (5554 cases and 123,548 controls) have been included in the review reporting genetic associations with carbamazepine (n=31), other aromatic antiepileptic drugs (n=24), abacavir (n=11), nevirapine (n=14), trimethoprim-sulfamethoxazole (n=11), dapsone (n=4), allopurinol (n=10), and other drugs (n=5). The most commonly reported genetic variants associated with DHRs are located in human leukocyte antigen genes and genes involved in drug metabolism pathways. Increasing our understanding of genetic variants that contribute to DHRs will allow us to improve diagnosis, develop new treatments, and predict and prevent DHRs in the future.
Mots clés
Stevens-Johnson syndrome, T-cell mediated hypersensitivity, abacavir, allopurinol, aromatic antiepileptic-drugs, carbamazepine, cutaneous adverse drug reactions, dapsone, drug rash with eosinophilia and systemic symptoms, drug-induced hypersensitivity syndrome, hypersensitivity syndrome, maculopapular exanthema, nevirapine, severe cutaneous adverse drug reaction, toxic epidermal necrolysis, trimethoprim-sulfamethoxazole
Référence
Allergy. 2020 Jan 3;:
