Changes in gray matter volume and functional connectivity in dementia with Lewy bodies compared to Alzheimer's disease and normal aging: implications for fluctuations.

Date publication

janvier 2020

Journal

Alzheimer's research & therapy

Auteurs

Membres identifiés du Cancéropôle Est :
Dr MUTTER Catherine , Dr NOBLET Vincent

Tous les auteurs :
Chabran E, Noblet V, Loureiro de Sousa P, Demuynck C, Philippi N, Mutter C, Anthony P, Martin-Hunyadi C, Cretin B, Blanc F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31907068

Résumé

Fluctuations are one of the core clinical features characterizing dementia with Lewy bodies (DLB). They represent a determining factor for its diagnosis and strongly impact the quality of life of patients and their caregivers. However, the neural correlates of this complex symptom remain poorly understood. This study aimed to investigate the structural and functional changes in DLB patients, compared to Alzheimer's disease (AD) patients and healthy elderly subjects, and their potential links with fluctuations.

Mots clés

Dementia with Lewy bodies, Fluctuations, Functional connectivity, MRI, Salience network, Voxel-based morphometry

Référence

Alzheimers Res Ther. 2020 Jan 6;12(1):9