Fiche publication
Date publication
mars 2016
Journal
Brain imaging and behavior
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DE SEZE Jérôme
,
Dr NOBLET Vincent
Tous les auteurs :
Ernst A, Noblet V, Denkova E, Blanc F, De Seze J, Gounot D, Manning L
Lien Pubmed
Résumé
Mental time travel (MTT) entails the ability to mentally travel into autobiographical memory (AM) and episodic future thinking (EFT). While AM and EFT share common phenomenological and cerebral functional properties, distinctive characteristics have been documented in healthy and clinical populations. No report, to our knowledge, has informed on the functional underpinnings of MTT impairment in multiple sclerosis (MS) patients, hence the aim of this work. We studied 22 relapsing-remitting MS patients and 22 matched controls. Participants underwent an AM/EFT assessment using the Autobiographical Interview (Levine et al. 2002), followed by a functional MRI session. The latter consisted in AM and EFT tasks, distinguishing the construction and elaboration phases of events. The results showed impaired performance for AM and EFT in patients, accompanied by increased cerebral activations mostly located in the frontal regions, which extended to the parietal, lateral temporal and posterior regions during AM/EFT tasks, relative to healthy controls. Enhanced brain activations in MS patients were particularly evident during the EFT task and involved the hippocampus, frontal, external temporal, and cingulate regions. The construction phase required greater fronto-parieto-temporal activations in MS patients relative to both healthy controls, and the elaboration phase. Taking together, our results suggested the occurrence of cerebral activation changes in the context of MTT in MS patients, expressed by distinct and common mechanisms for AM and EFT. This study may provide new insights in terms of cerebral activation changes in brain lesion and their application to clinical settings, considering AM/EFT's central role in everyday life.
Mots clés
Adult, Brain, physiopathology, Brain Mapping, Emotions, physiology, Female, Humans, Imagination, physiology, Interviews as Topic, Magnetic Resonance Imaging, Male, Memory, Episodic, Multiple Sclerosis, Relapsing-Remitting, physiopathology, Neuropsychological Tests, Reaction Time, Thinking, physiology
Référence
Brain Imaging Behav. 2016 Mar;10(1):296-313
